Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 97, Issue -, Pages 132-137Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.03.027
Keywords
Chitosan; Gold; Hydrogel; Controlled drug delivery
Funding
- National Natural Science Foundation of China [21074051, 51033002, 20874042]
- Fundamental Research Funds for the Central Universities [1085021309]
- Provincial Natural Science Foundation of Jiangsu Province [BK2010301]
- Alexander von Humboldt Foundation
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A novel chitosan-gold (CS-Au) hybrid hydrogel was developed from chitosan and chloroauric acid in aqueous solution. Its physiochemical characteristics, including UV absorption, structure, morphology, swelling properties were studied. The CS-Au hybrid hydrogel exhibited an excellent water-absorbing property and could be applied as a drug delivery system for anticancer drug: doxorubicin (DOX) due to its high equilibrium water swelling content. The drug loading and release experiments elicited an efficient drug loading content and sustained drug release pattern. Moreover, DOX released from hydrogel which itself had no cytotoxicity was biological active similar as the free DOX, but lower cytotoxicity due to its controllable release. All proved it an ideal local drug delivery system indicating a promising potential future in medical or pharmaceutical area. (C) 2012 Elsevier B.V. All rights reserved.
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