Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 90, Issue -, Pages 254-258Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2011.10.025
Keywords
Chitosan; SAXS; Nanoparticles; Coacervation; Polyelectrolyte complexes; Drug delivery
Funding
- Brazil's Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ-UFRN)
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Chitosan nanoparticles have been used in several systems destined to controlled release of active agents. In this manuscript the process of formation of chitosan nanoparticles, obtained employing the coacervation method with sodium sulfate is analyzed using zeta potential and small angle X-ray scattering (SAXS) measurements. Dispersions were obtained at pH = 1 and pH = 3 and presented a behavior, in terms of surface charging, that was independent of pH. However, SAXS results indicated a dependence of size-related behavior on pH. The difference in terms of behavior was explained through the influence of enthalpic and entropically driven components. (C) 2011 Elsevier B.V. All rights reserved.
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