Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 95, Issue -, Pages 254-257Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.03.008
Keywords
Magnetite nanoparticles; Magnetic hyperthermia; Uptake; Cancer; Magnetism
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [22651046, 20002006] Funding Source: KAKEN
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Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44 nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2 mV) and hydrodynamic size (similar to 1 mu m) and there was no significant difference in their uptake amount 18 h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4 kW, 250 kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content. (C) 2012 Elsevier B.V. All rights reserved.
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