Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 94, Issue -, Pages 288-295Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.02.003
Keywords
Nanoporous alumina; Silica nanotubes; Surface functionalization; Drug-delivery system; NSAIDs
Funding
- FCT [SFRH/BD/38445/2007, SFRH/BD/38290/2007, FEDER/POCTI n2-155/94, POCI/FP/81979/2007, CERN/FP/83643/2008]
- Fundacao Gulbenkian
- FCT through the Associated Laboratories-IN
- REQUIMTE
- Fundação para a Ciência e a Tecnologia [POCI/FP/81979/2007, CERN/FP/83643/2008, SFRH/BD/38290/2007, SFRH/BD/38445/2007] Funding Source: FCT
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A novel pH-sensitive drug delivery system based on functionalized silica nanotubes was developed for the incorporation of non-steroidal anti-inflammatory drugs (NSAIDs), aimed at a tailored drug release in acidic conditions characteristic of inflamed tissues. Silica nanotubes (SNTs) were synthesized by a nanoporous alumina template assisted sol-gel method. Inner surfaces were physically and chemically modified to improve both the functionalization and subsequent incorporation of the drug. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and transmission electron microscopy (TEM) were used to characterize the designed nanocarriers and their functionalization. To achieve the highest degree of functionalization, three types of aminosilanes were tested and calcination conditions were optimized. APTES was shown to be the most effective aminosilane regarding the functionalization of the SNTs' inner surface and an adequate calcination temperature (220 degrees C) was found to attain mechanical stability without compromising functionalization efficiency. Finally, the incorporation of naproxen into the nanotubes was accessed by fluorescence measurements and drug release studies were performed, revealing that the electrostatic linkage ensures effective release of the drug in the acidic pH typical of inflamed cells, while maintaining the SNT-drug conjugates stable at the typical bloodstream pH. (C) 2012 Elsevier B.V. All rights reserved.
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