Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 91, Issue -, Pages 242-249Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2011.11.007
Keywords
Blood-brain barrier; Nanoparticle; Polybutylcyanoacrylate; CRM197; Zidovudine
Funding
- National Science Council of the Republic of China
Ask authors/readers for more resources
This study investigates the capability of CRM197-grafted polybutylcyanoacrylate (PBCA) nanoparticles (NPs) (CRM197/PBCA NPs) to carry zidovudine (AZT) across the blood-brain barrier (BBB). AZT was loaded on CRM197/PBCA NPs to traverse the monolayer of human brain-microvascular endothelial cells (HBMECs) regulated by human astrocytes. The particle size distribution of AZT-loaded CRM197/PBCA NPs was quite uniform. In addition, AZT-loaded CRM197/PBCA NPs displayed a spherical shape with slightly fluffy exterior. The deposited thin film of AZT-loaded CRM197/PBCA NPs exhibited a hexagonal lattice-like geometry. When the diameter of AZT-loaded CRM197/PBCA NPs decreased, the loading efficiency of AZT on the drug carriers and the permeability coefficient of AZT across the BBB enhanced. An increase in the grafting quantity of CRM197 enhanced the permeability coefficient of AZT across the BBB and the uptake quantity of AZT-loaded CRM197/PBCA NPs by HBMECs. CRM197/PBCA NPs can be promising brain-targeting carriers for delivering AZT across the BBB. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available