Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 89, Issue -, Pages 223-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2011.09.020
Keywords
Polyrotaxane tri-block copolymer; Dynamic contact angle; Quartz crystal microbalance with dissipation; Molecular mobility; Protein adsorption
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A tri-block copolymer series containing hydrophilic polyrotaxane and hydrophobic poly(isobutylmethacrylate) (PiBMA) segments was prepared by atom transfer radical polymerization (ATRP), starting from a pseudopolyrotaxane consisting of 2-bromoisobutyryl end-capped poly(ethylene glycol) (PEG) and alpha-cyclodextrin (alpha-CD) and followed by methylation. The dynamic wettability and molecular mobility of the copolymer surfaces were evaluated by dynamic contact angle (DCA) and quartz crystal microbalance with dissipation (QCM-D) measurements, respectively. The polyrotaxane tri-block copolymer surfaces were found to show pronounced dynamic wettability and molecular mobility compared to the control surfaces-a tri-block polymer consisting of PEG and PiBMA, and a PiBMA homopolymer-suggesting that a polyrotaxane loop-like structure exists at the outermost surface in an aqueous environment and exhibits dynamic properties attributable to the possible mobile nature of hydrated alpha-CD molecules along the PEG backbone. Finally, excellent protein adsorption repellency was achieved on the polyrotaxane tri-block copolymer surface, presumably due to the mobile nature of the supramolecular architecture on the surface. (C) 2011 Elsevier B.V. All rights reserved.
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