Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 85, Issue 2, Pages 270-279Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2011.02.039
Keywords
Polysaccharide nanocrystals; Alginate; Microspheres; Release kinetics
Funding
- Energy Research and Development (PERD) of Natural Resources Canada
- Pulse Research Network (PURENet)
- National Natural Science Foundation of China [50843031]
- Chinese Ministry of Science and Technology [2007CB936104, 2009CB930300]
- Fundamental Research Funds for the Central Universities (Self-Determined and Innovative Research Funds of WUT) [2010-11-022]
- Shanghai Municipality Commission for Special Project of Nanometer Science and Technology [0952nm05300]
- Shanghai Municipality Commission for International Corporation Project [10410710000]
- Non-Governmental International Corporation Project [09540709000]
- State Key Laboratory of Pulp and Paper Engineering [200906]
- Key Laboratory of Cellulose and Lignocellulosics Chemistry, Guangzhou Institute of Chemistry [LCLC-2010-10]
- Key Laboratory for Attapulgite Science and Applied Technology of Jiangsu Province [HPK201003]
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Polysaccharide nanocrystals, such as rod-like cellulose nanocrystals and chitin whiskers and platelet-like starch nanocrystals, were incorporated into alginate-based nanocomposite microspheres with the aim of enhancing mechanical strength and regulating drug release behavior. The structures and properties of the sols and the resultant nanocomposite microspheres were characterized by rheological testing, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The presence of polysaccharide nanocrystals increased the stability of the crosslinked network structure, and the nanocomposite microspheres consequently exhibited prominent sustained release profiles, as demonstrated by inhibited diffusion of theophylline. Furthermore, based on the drug release results, the release kinetics and transport mechanisms were analyzed and discussed. Crown Copyright (C) 2011 Published by Elsevier By. All rights reserved.
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