Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 82, Issue 2, Pages 297-301Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2010.08.045
Keywords
Tea polyphenols; Carboxymethyl chitosan; Chitosan hydrochloride; Nanoparticles; Cytotoxicity
Funding
- National Natural Science Foundation of China [30871743]
- Education Ministry of China [B07030]
- National High Technology Research and Development Program of China [2007AA100403]
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Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407 +/- 50 nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8-16% and 44-83%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities. (C) 2010 Elsevier B.V. All rights reserved.
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