Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 83, Issue 1, Pages 183-187Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2010.11.023
Keywords
Selenium; Nanoparticles; Sialic acid; Cellular uptake; Apoptosis
Funding
- Natural Science Foundation of China and Guangdong Province
- Natural Science Foundation of Guangdong Province
- Science and Technology Department of Guangdong Province
- Fundamental Research Funds for the Central Universities
- China Postdoctoral Science Foundation
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A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP. (C) 2010 Elsevier B.V. All rights reserved.
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