Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 86, Issue 2, Pages 275-284Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2011.04.007
Keywords
Hot-melt extrusion; Taste masking; Orally disintegrating tablets Eudragit EPO
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In the current study Ibuprofen was embedded in a methacrylate copolymer (Eudragit (R) EPO) matrix to produce solid dispersions by hot-melt extrusion (HME) processing. The obtained granules were incorporated in orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and crosslinked polyvinylpyrrolidone grades while a direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets which included porosity, hardness, friability and dissolution profiles were further evaluated and compared with Nurofen (R) Meltlet ODTs. The taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and improved tablet palatability. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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