Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 82, Issue 2, Pages 325-332Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2010.09.004
Keywords
Functionalization; N-vinyl-2-pyrrolidone; Ornidazole; Antidiarrheal
Ask authors/readers for more resources
In view of the antidiarrheal properties of sterculia gum and ornidazole, an attempt has been made to synthesize novel hydrogels by functionalization of sterculia gum with poly(vinylpyrrolidone) (PVP) for release of the model antidiarrheal drug ornidazole. These hydrogels were characterized with FUR. SEM, TGA and swelling behavior. Swelling kinetics of the hydrogels and in vitro release dynamics of ornidazole from the drug loaded hydrogels have been studied to determine the mechanism of swelling and drug release from the drug loaded hydrogels. A Fickian diffusion mechanism has been observed for the release of drug from the hydrogels. These hydrogels may have dual actions for the treatment of diarrhea. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available