Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 88, Issue 1, Pages 221-230Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2011.06.036
Keywords
Liposome; Dynamics; Dielectric dispersion; Headgroup; Hydrogen bonding; Hydrophobicity
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21246121, 23656525]
- JSPS
- Vietnamese Academy of Science and Technology (VAST)
- Cabinet Office, Government of Japan [GR066]
- Grants-in-Aid for Scientific Research [23656525, 21246121] Funding Source: KAKEN
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In this study, we investigated the dynamics of a membrane interface of liposomes prepared by eight zwitterionic phosphatidylcholines in terms of their headgroup mobility, with spectroscopic methods such as dielectric dispersion analysis (DDA), fluorescence spectroscopy. The DDA measurement is based on the response of the permanent dipole moment to a driving electric field and could give the information on the axial rotational Brownian motion of a headgroup with the permanent dipole moment. This motion depended on kinds of phospholipids, the diameter of the liposomes, and the temperature. The activation energy required to overcome the intermolecular force between headgroups of phospholipids depended on the strength of the interaction between headgroups such as hydrogen bonds and/or dipole-dipole interaction. Hydration at the phosphorous group of phospholipid and the molecular order of lipid membrane impaired the interaction between headgroups. Furthermore, the hydrophobicity of membrane surface increased parallel to the increase in headgroup mobility. It is, therefore, concluded that hydration of headgroup promoted its mobility to make the membrane surface hydrophobic. The lipid membrane in liquid crystalline phase or the lipid membrane with the larger curvature was more hydrophobic. (C) 2011 Elsevier B.V. All rights reserved.
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