Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 80, Issue 2, Pages 184-192Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2010.06.002
Keywords
Quercetin; PLA; Nanoparticles; Encapsulation efficiency; Antioxidant; In vitro release
Funding
- Council of Scientific and Industrial Research (CSIR)
- Women Scientists Scheme (A) [SR/WOS-A/CS-61/2008]
- Department of Science and Technology (DST), Government of India
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The antioxidant molecule quercetin has been encapsulated on poly-D,L-lactide (PLA) nanoparticles by solvent evaporation method for the improvement of its poor aqueous solubility and stability. The surface morphology and average size of PLA and quercetin loaded PLA nanoparticles are 170 +/- 25 and 130 +/- 30 nm respectively. The antioxidant activities of the PLA encapsulated quercetin nanomedicine are identical to free quercetin. The nanoencapsulation efficiency of quercetin evaluated by HPLC and antioxidant assay is 96.7%. The in vitro release kinetics under physiological condition show initial burst release followed by slow and sustained release. The complete release and maximum retention of quercetin is 72 and 96 h respectively. The less fluorescence quenching efficiency of quercetin-PLA nanoparticles than free quercetin on BSA confirms the controlled release of quercetin from PLA nanoparticles. These properties of PLA encapsulated quercetin molecule pave way for encapsulating various therapeutically less useful highly active antioxidant molecules towards the development of better therapeutic compounds. (C) 2010 Elsevier B.V. All rights reserved.
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