Voltammetric sensor for buzepide methiodide determination based on TiO2 nanoparticle-modified carbon paste electrode

In this work, we have prepared nano-material modified carbon paste electrode (CPE) for the sensing of an antidepressant, buzepide methiodide (BZP) by incorporating TiO2 nanoparticles in carbon paste matrix. Electrochemical studies indicated that the TiO2 nanoparticles efficiently increased the electron transfer kinetics between drug and the electrode. Compared with the nonmodified CPE, the TiO2-modified CPE greatly enhances the oxidation signal of BZP with negative shift in peak potential. Based on this, we have proposed a sensitive, rapid and convenient electrochemical method for the determination of BZP. Under the optimized conditions, the oxidation peak current of BZP is found to be proportional to its concentration in the range of 5 x 10(-5) to 5 x 10(-5) M with a detection limit of 8.2 x 10(-9) M. Finally, this sensing method was successfully applied for the determination of BZP in human blood serum and urine samples with good recoveries. (C) 2010 Elsevier B.V. All rights reserved.