Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 76, Issue 1, Pages 292-297Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.11.007
Keywords
Chitosan; Ascorbyl palmitate; Encapsulation; Nanoparticles; Emulsion; Ionic cross-linking
Funding
- Thailand Research Fund [IRPUS/1250B02002]
- Kasetsart University, Thailand [AI-01-50]
- International Laboratories Corp., Ltd., Thailand
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The encapsulation of ascorbyl palmitate (AP) in chitosan particles was carried out by droplet formation via an oil-in-water emulsion, followed by droplet solidification via ionic gelation using sodium triphosphate pentabasic (TPP) as a cross-linking agent. The success of AP encapsulation was confirmed by FT-IR, UV-vis spectrophotometry, TGA, and XRD techniques. The obtained AP-loaded chitosan particles were spherical in shape with an average diameter of 30-100 nm as observed by SEM and TEM. Loading capacity (LC) and encapsulation efficiency (EE) of AP in the nanoparticles were about 8-20% and 39-77%, respectively, when the initial AP concentration was in the range of 25-150% (w/w) of chitosan, Augmentation of the initial AP concentration led to an increase of LC and a reduction of EE. The amount of AP released from the nanoparticles in ethanol and tris buffet (pH similar to 8.0) increased with increasing LC and decreasing TPIP concentration. (C) 2009 Elsevier B.V. All rights reserved.
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