Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 76, Issue 2, Pages 549-555Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.12.017
Keywords
Layer-by-layer; PH; Silver nanoparticles; In situ; Nanocomposite
Funding
- Natural Science Foundation of China [NSFC-20774082, 50830106]
- Major State Basic Research Foundation of China [2005CB623902]
- 863 National High-Tech RD Program [2006AA03Z329, 2006AA03Z444]
- Ph.D. Programs Foundation of Ministry of Education of China [20070335024]
- Science and Technology Projects of Zhejiang Province [2007C24008]
- Open Project of State Key Laboratory of Supramolecular Structure and Materials [SKLSSM200911]
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Chitosan and heparin multilayer films were successfully constructed via layer-by-layer self assembly. These films were used as a polymeric template to synthesize silver nanoparticles. The silver concentration and nanoparticle size can be simply controlled by the assembly pH and loading pH, as demonstrated by UV-visible spectroscopy, transmission electron microscopy and atomic absorbance spectroscopy. The pH tunable uncompensated charge density within the multilayer films is believed to have great effect on the loading of silver ions, and then control the size and amount of silver nanoparticles within multilayer films. The antibacterial experiment shows that the silver nanoparticle-loaded chitosan/heparin multilayer films exhibit greatly enhanced antibacterial performance compared to the chitosan/heparin multilayer films without silver nanoparticles. in addition, the strong antibacterial property of silver nanoparticle-loaded films can last more than I month. Our method of in situ synthesis of metal nanoparticles in biocompatible multilayer films might provide great potential to design biofunctional nanocomposite films. (C) 2009 Elsevier B.V. All rights reserved.
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