4.7 Article

Effect of surface modification on the in vitro calcium phosphate growth on the surface of poly(methyl methacrylate) and bioactivity

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 76, Issue 1, Pages 326-333

Publisher

ELSEVIER
DOI: 10.1016/j.colsurfb.2009.11.012

Keywords

Calcium phosphate; PMMA; XPS; FT-IR; FE-SEM; Osteoblast

Ask authors/readers for more resources

Poly(methyl methacrylate) (PMMA) is a biocompatible polymer widely used for bone substitutes. Its Surface properties, however, are not favorable for the induction of biological apatite which can be directly related to natural bone formation. In this study, the Surface of PMMA was modified by NaOH treatment OF sequential treatments with ethanol (EtOH) and NaOH. Results displayed that surface hydrophilicity was improved for increasing treatment time and NaOH concentration. Field-emission scanning electron microscope (FE-SEM) displayed that in vitro formation of calcium phosphate (Cap) coating was significantly promoted by the surface modifications. X-ray photon spectroscopy (XPS) examination elucidated that the films prepared on PMMA consisted of Calcium and phosphorus and their values for Ca/P ratio were closed to octacalcium phosphate (OCP). Fourier transform infrared (FT-IR) spectra of the him coated on PMMA revealed a band characteristic of phosphate groups confirming that CaP films were formed and their characteristics were dependent on the surface Properties of PMMA. Cellular assay demonstrated that the adhesion of osteoblast-like MG63 cells was significantly promoted on CaP-coated PMMA. Proliferation assay showed that CaP films appeared not to exert any cytotoxic effects on the growth of MG63 cells. (C) 2009 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available