Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 74, Issue 1, Pages 1-16Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2009.06.021
Keywords
Chitosan; Chitosan derivatives; Hydrophobic substitution; Surface active properties; Aggregation behavior; Drug encapsulation; Surface interactions
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This review discusses the definition of surface active agents and specifically natural polymeric Surface active agents. Chitosan by itself was found to have weak surface activity since it has no hydrophobic segments. Chemical modifications of chitosan could improve Such surface activity. This is achieved by introducing hydrophobic substituents in its glucosidic group. Several examples of chitosan derivatives with surfactant activity have been Surveyed. The surface active polymers form micelles and aggregates which have enormous importance in the entrapment of water-insoluble drugs and consequently applications in the controlled drug delivery and many biomedical fields. Chitosan also interacts with several substrates by electrostatic and hydrophobic interactions with considerable biomedical applications. (C) 2009 Elsevier B.V. All rights reserved.
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