Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 74, Issue 1, Pages 253-259Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.07.027
Keywords
Polymeric micelles; Anticancer agent; Camptothecin; Cholic acid chitosan
Funding
- Commission of Higher Education (Thailand)
- Thailand Research Funds through the Royal Golden jubilee Ph.D. Program [PHD/0104/2549]
- National Nanotechnology Center (NANOTEC), Thailand [NN-B-22-EN5-17-50-12]
- National Research Council of Thailand
- Center of Innovation Nanomaterials, Chulalongkorn University
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A water-insoluble anticancer agent, camptothecin (CPT) was incorporated to a polymeric micelle carrier system preparing from cholic acid chitosan-grafted poly (ethylene glycol) methyl ether (CS-mPEG-CA). CS-mPEG-CA formed a core-shell micellar structure with a critical micelle concentration (CMC) of 7.08 mu g/ml. Incorporation efficiency was investigated by varying physical incorporation method and initial drug loading. Among three incorporation methods (dialysis, emulsion and evaporation methods), an emulsion method showed the highest CPT incorporation efficiency. Increasing the initial CRT loading from 5 to 40%, the incorporation efficiency decreased. In all examined CPT-loaded CS-mPEG-CA micelles. 5% initial drug loading showed the highest drug incorporation efficiency. Release of CPT from the micelles was sustained when increasing the initial CPT loading. This indicates the importance of incorporation method and the initial drug loading to obtain the optimum particle size with high drug loading and sustained drug release. When compared to the unprotected CPT, CPT-loaded CS-mPEG-CA micelles were able to prevent the hydrolysis of the lactone group of the drug. This novel CS-mPEG-CA polymer presents considerable potential interest in the further development of CRT carrier. (c) 2009 Elsevier B.V. All rights reserved.
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