Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 71, Issue 2, Pages 194-199Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.02.010
Keywords
Surface modification; Latex particles; Activator generated electron transfer atom transfer; Radical polymerization (AGET ATRP); Lactose; Core-shell; Dispersion stability; Adsorption; Bovine serum albumin (BSA)
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Grafting of a styrene derivative bearing a lactose residue, i.e., N-2-4-(vinylbenzenesulfonamido)ethyl lactobionamide (VBSAELA), onto polymer latex particles was carried out in aqueous media by activator generated electron transfer atom transfer radical polymerization (AGET ATRP). The core polymer latex particles having alpha-chloroester groups as ATRP-initiating groups were prepared by miniemulsion polymerization of styrene and 2-chloropropionyloxyethyl methacrylate (CPEM) in the presence of a polymerizable surfactant, i.e., N,N-dimethyl-N-dodecyl-N-2-methacryloyloxyethylammonium bromide (C12Br). AGET ATRP was initiated with tris[(2-pyridylmethyl)amine] copper (II) dichloride and L-ascorbic acid. Dynamic light scattering (DLS) revealed that the P(St-CPEM)-g-P(VBSAELA) particles possess graft layers of 10 nm in thickness on the core particles of 91 nm in diameter. Critical coagulation concentration measurement revealed that the dispersion stability of the particles in water increased due to hydrated P(VBSAELA) shell layers. Adsorption of bovine serum albumin (BSA) onto the particles was considerably suppressed by the hydrated shell layers. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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