Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 73, Issue 1, Pages 51-57Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2009.04.025
Keywords
Bacillus licheniformis; Silver nanoparticles; Diabetic retinopathy; Primary bovine retinal endothelial cells
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Angiogenesis, the growth of new blood vessels from pre-existing vasculature is of physiological and pathological importance. We have investigated the anti-angiogenic potential of silver nanoparticles, produced by Bacillus licheniformis. Bovine retinal endothelial cells (BRECs) were treated with the different concentrations of silver nanoparticles for 24 h in the presence and absence of vascular endothelial growth factor (VEGF), where 500 nM (IC50) of silver nanoparticle concentration, was able to block the proliferation and migration of BRECs. The cells showed a clear enhancement in caspase-3 activity and formation of DNA ladders, evidence of induction of apoptosis. Here we report for the first time that silver nanoparticles inhibit cell survival via PI3K/Akt dependent pathway in Bovine retinal endothelial cells. (C) 2009 Elsevier B.V. All rights reserved.
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