Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization camptothecin

To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P 105 (P 105) and D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle concentration (CMC) was used to evaluate the micellar stability towards dilution. Poorly soluble anticancer drug CPT was incorporated into the mixed micelles. The solubility of CPT by the mixed micelles was more than that of the free drug. The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell in vitro was remarkably higher than that of the free drug. (c) 2008 Elsevier B.V. All rights reserved.