Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 62, Issue 1, Pages 146-150Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2007.09.013
Keywords
biosensor; Con A; alkanethiol/glycolipid vesicles; electrochemistry
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Functionalized vesicles composed of glycolipid and alkanethiol lipids have been immobilized onto gold surface through one-step self-assembly to construct an electrochemical biosensor for Concanavalin A (Con A) detection. Incorporation of alkanethiol lipid molecules into the vesicles allows for firm attachment of the vesicles onto a gold surface to form a sensing interface. At the same time, the introduction of alkanethiol lipid avoids cumbersome organic syntheses of sulfur-containing compound, making the biosensor greater applied prospect. Through the recognition of Con A by glycolipid which was immobilized on the surface of electrode, a decrease of electrochemical signal was observed. This decrease was restored when the electrode was immersed in a stronger binding solution such as glucose. The repeated usability of the novel sensor is excellent. (c) 2007 Elsevier B.V. All rights reserved.
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