Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 462, Issue -, Pages 75-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2014.08.028
Keywords
Chitosan nanoparticles; Freeze-drying; Ultrasonication; Ionic gelation
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [104M412]
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Chitosan nanoparticles have been prepared using an ionic gelation method. The effects of freeze-drying, cryoprotectant (D-trehalose) utilisation and ultrasonication time on the mean particle size, size distribution and stability of nanoparticles were investigated. The size distribution results indicated that freeze-drying caused the particles to agglomerate. Addition of the cryoprotectant and ultrasonication led to a decrease in the particle size. However the sizes of the nanoparticles increased with increasing ultrasonication time. Transmission electron microscopy images revealed that spherical chitosan nanoparticles ranging from 3 to 12 nm were obtained by means of freeze-drying in the presence of cryoprotectant and ultrasonication. These results suggest that cryoprotectant utilisation and controlled ultrasonic treatment are effective for imparting nanoparticle stability. (C) 2014 Elsevier B.V. All rights reserved.
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