Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 436, Issue -, Pages 1092-1102Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2013.08.056
Keywords
Sub-100 nm polymeric nanoparticles; Light scattering; Nanoprecipitation
Categories
Funding
- FAPESP [2012/14087-8, 2012/17841-5]
- GACR [202/09/2078]
- Charles University
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/17841-5] Funding Source: FAPESP
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Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (R-H) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer-solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. (C) 2013 Elsevier B.V. All rights reserved.
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