Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 403, Issue -, Pages 7-14Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2012.03.017
Keywords
Mesoporous silica nanoparticles; Dual-stimuli-responsive; Magnetic oriented target; pH-responsive; Drug release
Categories
Funding
- National Native Science Foundation of China [21171045, 21101046]
- Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang province [2011TD010]
- Harbin Normal University [YJSCX2011-404HLJ]
Ask authors/readers for more resources
A dual-stimuli-responsive drug delivery system, with magnetic oriented target and pH-sensitive characters, has been prepared. The materials show highly ordered mesostructure, high pore volume, regular nanoparticle morphology (500 nm), and superior magnetic property. The materials were characterized by XRD, TEM, BET, FTIR and vibrating sample magnetometer technique (VSM). The pH-sensitive magnetic mesoporous silica nanoparticles (MMSNs) was served as a drug carrier, with ibuprofen (IBU) being the model drug. The release kinetics in simulated gastric fluid (SGF, pH 1.2) and in simulated proximal intestine fluid (SIF, pH 7.4) were studied respectively. It is found that the drug release increased rapidly when the release medium was changed from SGF to SIF. These dual-functional drug delivery systems with magnetically oriented target and pH-responsive performances may predictably have application in biomedical field. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available