Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 380, Issue 1-3, Pages 169-174Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2011.02.038
Keywords
Magnetic nanoparticle; Chitosan; Sulfonation; Catecholamines; Conjugation
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Funding
- National Nature Science Foundation of China [NSFC-60771023]
- Program for New Century Excellent Talents in University [NCET-08-0122]
- Ministry of Education
- Nature Science Foundation of Jiangsu Province [BK2008304]
- Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities, Jiangsu Province [CX08B-145Z]
- Innovation Research Foundation of Southeast University for Doctor Students, Southeast University, China [BC0905]
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We synthesized a novel magnetic nanoparticle coated with sulfonated complex (HSO3-CS-DMSA) of meso-2, 3-dimercaptosuccinic acid (DMSA) and chitosan (CS) to improve conjugation of catecholamines (CAs) on nanoparticles. HSO3-CS-DMSA@MNPs exhibited the highest CAs' conjugation efficiency among three types of magnetic nanoparticles. CAs' conjugation efficiency was increased in order of MNPs, DMSA@MNPs and HSO3-CS-DMSA@MNPs. CAs' conjugation efficiency at pH 7 depended on zeta potential of magnetic nanoparticles and catecholamines were partly desorbecl after being washed with acidic solutions. These results showed that the electrostatic interaction between the negatively charged nanoparticles and positively charged amino groups of catecholamines might play an important role in CAs' conjugation on magnetic nanoparticles. (C) 2011 Elsevier B.V. All rights reserved.
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