Journal
COLLOID AND POLYMER SCIENCE
Volume 296, Issue 11, Pages 1827-1839Publisher
SPRINGER
DOI: 10.1007/s00396-018-4406-8
Keywords
Block glycopolymers; Bortezomib; Dynamic covalent bonding; Self-assembly; Controlled release
Categories
Funding
- National Natural Science Foundation of China [51473035, 21204010]
- Research Program of Shanghai Science and Technology Commission [13NM1400102]
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and the Innovative Research Team in University [T2011079, IRT1221]
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To explore block glycopolymers as novel polymeric delivery nanocarriers for anticancer drug bortezomib (BTZ), three types of block glycopolymers, poly(ethylene glycol)-block-poly(gluconamido ethyl methacrylate) (PEG(113)-b-PGAMA(20)), poly(ethylene glycol)-block-poly(styrene)-block-poly(gluconamido ethyl methacrylate) (PEG(113)-b-PS50-b-PGAMA(20)), and poly(ethylene glycol)-block-poly(2-(diethyl amino) ethyl methacrylate)-block-poly(gluconamido ethyl methacrylate) (PEG(113)-b-PDEA(50)-b-PGAMA(20)), were synthesized via atom transfer radical polymerization (ATRP) using a PEG-based ATRP macroinitiator. Three glycopolymers possess the capacity to load BTZ via pH-induced dynamic covalent bonding and/or hydrophobic interaction with their specific self-assembly behaviors, and PEG(113)-b-PS50-b-PGAMA(20) carrier maintains the sustain release behavior of BTZ due to the stable micellar structure; PEG(113)-b-PDEA(50)-b-PGAMA(20) carrier realizes the abrupt release at pH5.5 by collapse of micellar structure, while PEG(113)-b-PGAMA(20) carrier exhibits the fastest release at studied solution pHs. This study would provide a light to develop novel block glycopolymer carrier for the delivery of anticancer drug bearing boronic acid groups.
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