Journal
COLLOID AND POLYMER SCIENCE
Volume 292, Issue 7, Pages 1619-1625Publisher
SPRINGER
DOI: 10.1007/s00396-014-3206-z
Keywords
Vesicles; Amino acid; Biosurfactant; Membrane; Polyethylene glycol-2000; Hydrogen bonding; Adsorption; Melting temperature
Categories
Funding
- Universiti Kebangsaan Malaysia [UKM-MI-OUP-2011 (13-00-09-001), UKM-DIP-2012-32, DPP-2013-052]
Ask authors/readers for more resources
Polyethylene glycol (PEG)-modified amino acid surfactant-based vesicles were prepared to improve the stability and cellular delivery of drugs. The vesicles comprised PEG-2000, sodium N-lauroylsarcosinate hydrate (SNLS), 1-decanol, and deionized water. The complex showed vesicular structures that were almost the same as the original vesicles, and their size distribution was (100-150 nm). Transmission electron microscopy (TEM) results revealed that no fusion occurred at 1.25 wt.% PEG concentration. The steric hindrance present among the vesicles prevented aggregation of the particles. No visual phase separation was observed for 6 months at room temperature 28 A(0)C. At higher molar concentration of PEG, fusion and wrinkling occurred owing to the association of PEG chains. The decreasing bending curvature led to the formation of fused vesicles with multilayer structure, as revealed by TEM and differential scanning calorimetry (DSC).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available