Journal
COLLOID AND POLYMER SCIENCE
Volume 289, Issue 5-6, Pages 667-675Publisher
SPRINGER
DOI: 10.1007/s00396-010-2337-0
Keywords
Shell cross-linked; Micelle; Tumor targeting; Drug release
Categories
Funding
- National Natural Science Foundation of China [20974083]
- Ministry of Science and Technology of China [2009CB930300]
- Natural Science Foundation of Hubei Province, China [2009CDA024]
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Thermosensitive amphiphilic poly(N-acroyloxysuccinimide)-b-poly(N-isopropylacrylamide)-b-poly(epsilon-caprolactone) triblock copolymer was synthesized via the combination of reversible addition fragmentation chain transfer and ring-opening polymerization techniques. Shell cross-linked micelle (SCL) was further developed by the addition of cystamine as a di-functional cross-linker into the micellar solution. The persistence of regularly spherical shape against media change demonstrated locked micellar structure resulting from sufficient shell cross-linking. The lower critical solution temperature of the resulting SCL micelles was around 38 A degrees C. The in vitro drug release study was carried out to illustrate the temperature-responsive drug release behaviors. To enhance the internalization to tumor cells, transferring (Tf) was further conjugated to the SCL micelles, and endocytosis experiments further confirmed the efficient uptake of Tf-SCL micelles by tumor cells, indicating that the Tf-SCL micelles would be a promising candidate for tumor-targeted drug delivery.
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