Journal
COGNITIVE NEURODYNAMICS
Volume 5, Issue 3, Pages 241-251Publisher
SPRINGER
DOI: 10.1007/s11571-011-9169-6
Keywords
Gamma oscillation; Fast-spiking interneurons; Pyramidal neuron; Inhibition; Neural network
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Funding
- Hong Kong University Grants Council [PolyU 5279/08E]
- MEXT [KAKENHI 21700366, 20246026]
- EC Framework Programme 7 [12788]
- Daiwa Anglo-Japanese Foundation
- Grants-in-Aid for Scientific Research [20246026, 21700366] Funding Source: KAKEN
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Networks of synchronized fast-spiking interneurons are thought to be key elements in the generation of gamma (c) oscillations (30-80 Hz) in the brain. We examined how such gamma-oscillatory inhibition regulates the output of a cortical pyramidal cell. Specifically, we modeled a situation where a pyramidal cell receives inputs from gamma-synchronized fast-spiking inhibitory interneurons. This model successfully reproduced several important aspects of a recent experimental result regarding the gamma-inhibitory regulation of pyramidal cellular firing that is presumably associated with the sensation of whisker stimuli. Through an in-depth analysis of this model system, we show that there is an obvious rhythmic gating effect of the gamma-oscillated interneuron networks on the pyramidal neuron's signal transmission. This effect is further illustrated by the interactions of this interneuron network and the pyramidal neuron. Prominent power in the gamma frequency range can emerge provided that there are appropriate delays on the excitatory connections and inhibitory synaptic conductance between interneurons. These results indicate that interactions between excitation and inhibition are critical for the modulation of coherence and oscillation frequency of network activities.
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