Journal
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
Volume 9, Issue 1, Pages 83-90Publisher
PSYCHONOMIC SOC INC
DOI: 10.3758/CABN.9.1.83
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Funding
- NIH [R01-HD042974]
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Dopamine plays a critical role in regulating neural activity in prefrontal cortex (PFC) and modulates cognition via a hypothesized inverse U function. We investigated PFC function in children with chromosome 22q11.2 deletion syndrome (22q11.2DS) in which one copy of catechol-O-methyltransferase (COMT) is deleted, thereby shifting them toward the lower end of dopamine turnover on the nonlinear function. A common polymorphism with valine to methionine substitution alters COMT activity that results in higher enzyme activity in the valine variant. Twenty-seven children with 22q11.2DS between 7 and 14 years old, and 21 age-matched typically developing children, performed a modified version of the Attention Network Test Children with a single valine allele showed a reduction in response times when trials with incongruent flankers; were repeated, whereas those who were hemizygous for the methionine allele did not show the same context-based response facilitation. Our results support that a single gene, COMT, could modulate PFC-dependent cognition.
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