Journal
CNS SPECTRUMS
Volume 19, Issue -, Pages 57-68Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1092852914000613
Keywords
atypical antipsychotic; serotonin; SERT; vortioxetine; vilazodone
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Funding
- Takeda Pharmaceuticals International, Inc.
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Major depressive disorder (MDD) is a serious and often crippling psychiatric illness with a high risk of relapse and treatment resistance. In this article, we discuss the role of the serotonergic system in MDD including our current understanding of how various serotonin (5HT) receptorsmodulatemonoamine neurotransmission and behavior. We also discuss how pharmacologic interventions, including novel and existing antidepressants and atypical antipsychotics, may be utilized to adjust serotonergic neurotransmission and provide more effective treatments for patients with MDD.
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