Journal
CNS NEUROSCIENCE & THERAPEUTICS
Volume 21, Issue 2, Pages 83-91Publisher
WILEY
DOI: 10.1111/cns.12353
Keywords
Development; GABA; Neonate; Seizure
Categories
Funding
- ANR [ANR-09-MNPS-006]
- Government of the Russian Federation [11.G34.31.0075]
- Government of the Russian Federation (program of competitive growth of Kazan University)
- FRM [DEQ20110421301]
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Early in development, GABA, which is the main inhibitory neurotransmitter in adult brain, depolarizes immature neurons and exerts dualexcitatory and shunting/inhibitoryeffects in the developing neuronal networks. The present review discusses some general questions, including the properties of excitation at depolarizing GABAergic synapse and shunting inhibition by depolarizing GABA; technical issues in exploration of depolarizing GABA using various techniques and preparations, including the developmental aspects of traumatic injury and what is known (or rather unknown) on the actions of GABA in vivo; complex roles of depolarizing GABA in developmental epilepsies, including a contribution of depolarizing GABA to enhanced excitability in the immature networks, caused by repetitive seizures accumulation of intracellular chloride concentration that increases excitatory GABA power and its synchronizing proconvulsive effects, and correction of chloride homeostasis as a potential strategy to treat neonatal seizures.
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