Journal
CNS NEUROSCIENCE & THERAPEUTICS
Volume 19, Issue 1, Pages 20-29Publisher
WILEY
DOI: 10.1111/cns.12013
Keywords
Apoptosis; bFGF; ER stress; ERK1; 2; PI3K; Akt; Spinal cord injury
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Funding
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
- National Natural Science Funding of China [81200958]
- State Key Basic Research Development Program [2012CB518105]
- Zhejiang Provincial Project of Key Group [2010R50042-02]
- Zhejiang Provincial Natural Science Foundation [R2090550]
- Wenzhou Medical College Research Foundation [QTJ11013]
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Aim To investigate the mechanism of endoplasmic reticulum (ER) stressinduced apoptosis as well as the protective action of basic fibroblast growth factor (bFGF) both in vivo and in vitro. Methods and Results ER stressinduced apoptosis was involved in the injuries of spinal cord injury (SCI) model rat. bFGF administration improved the recovery and increased the survival of neurons in spinal cord lesions in model rat. The protective effect of bFGF is related to the inhibition of CHOP, GRP78 and caspase-12, which are ER stressinduced apoptosis response proteins. bFGF administration also increased the survival of neurons and the expression of growth-associated protein 43 (GAP43), which is related to neural regeneration. The protective effect of bFGF is related to the activation of downstream signals, PI3K/Akt/GSK-3 beta and ERK1/2, especially in the ER stress cell model. Conclusions This is the first study to illustrate that the role of bFGF in SCI recovery is related to the inhibition of ER stressinduced cell death via the activation of downstream signals. Our work also suggested a new trend for bFGF drug development in central neural system injuries, which are involved in chronic ER stressinduced apoptosis.
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