Journal
CNS NEUROSCIENCE & THERAPEUTICS
Volume 15, Issue 4, Pages 345-357Publisher
WILEY
DOI: 10.1111/j.1755-5949.2009.00105.x
Keywords
Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Melatonin; Mitochondrial cell death pathways; Parkinson disease; Stroke; Survival signal pathways
Categories
Funding
- National Institutes of Health/National Institute of Neurological Disorders and Stroke
- Hereditary Disease Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K01NS055072] Funding Source: NIH RePORTER
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Melatonin plays a neuroprotective role in models of neurodegenerative diseases. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Apoptotic cell death in the central nervous system is a feature of neurodegenerative diseases. The intrinsic and extrinsic apoptotic pathways and the antiapoptotic survival signal pathways play critical roles in neurodegeneration. This review summarizes the reports to date showing inhibition by melatonin of the intrinsic apoptotic pathways in neurodegenerative diseases including stroke, Alzheimer disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis. Furthermore, the activation of survival signal pathways by melatonin in neurodegenerative diseases is discussed.
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