Related references
Note: Only part of the references are listed.Lead optimization in the nondrug-like space
Hongyu Zhao
DRUG DISCOVERY TODAY (2011)
Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
Markus Heilig et al.
ADDICTION BIOLOGY (2010)
Interactions of Stress and CRF in Ethanol-Withdrawal Induced Anxiety in Adolescent and Adult Rats
Tiffany A. Wills et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2010)
Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism
Shawn M. Vuong et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats
Adrie W. Bruijnzeel et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Corticotropin Releasing Factor-Induced Amygdala Gamma-Aminobutyric Acid Release Plays a Key Role in Alcohol Dependence
Marisa Roberto et al.
BIOLOGICAL PSYCHIATRY (2010)
The role of CRF and CRF-related peptides in the dark side of addiction
George F. Koob
BRAIN RESEARCH (2010)
Progress in corticotropin-releasing factor-1 antagonist development
Eric P. Zorrilla et al.
DRUG DISCOVERY TODAY (2010)
Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal
Balaji Krishnan et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2010)
CRF-1 Antagonist and CRF-2 Agonist Decrease Binge-Like Ethanol Drinking in C57BL/6J Mice Independent of the HPA Axis
Emily G. Lowery et al.
NEUROPSYCHOPHARMACOLOGY (2010)
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
Thomas N. Greenwell et al.
ADDICTION BIOLOGY (2009)
Sensitization, Duration, and Pharmacological Blockade of Anxiety-Like Behavior Following Repeated Ethanol Withdrawal in Adolescent and Adult Rats
Tiffany A. Wills et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)
The Alcohol Deprivation Effect in C57BL/6J Mice is Observed Using Operant Self-Administration Procedures and is Modulated by CRF-1 Receptor Signaling
Dennis R. Sparta et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)
Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice
Amanda L. Sharpe et al.
BEHAVIOURAL PHARMACOLOGY (2009)
Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain Reward Function and Stress-Induced Relapse
Adrie W. Bruijnzeel et al.
BIOLOGICAL PSYCHIATRY (2009)
Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis
Walter Francesconi et al.
JOURNAL OF NEUROSCIENCE (2009)
Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons
Junghyun Hahn et al.
JOURNAL OF NEUROSCIENCE (2009)
Mechanisms of Withdrawal-Associated Increases in Heroin Self-Administration: Pharmacologic Modulation of Heroin vs Food Choice in Heroin-Dependent Rhesus Monkeys
S. Stevens Negus et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Corticotropin-Releasing Factor Within the Central Nucleus of the Amygdala and the Nucleus Accumbens Shell Mediates the Negative Affective State of Nicotine Withdrawal in Rats
Catherine A. Marcinkiewcz et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Gene-environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1
Toni-Kim Clarke et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2009)
CRF system recruitment mediates dark side of compulsive eating
Pietro Cottone et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Deficit in brain reward function and acute and protracted anxiety-like behavior after discontinuation of a chronic alcohol liquid diet in rats
Daria Rylkova et al.
PSYCHOPHARMACOLOGY (2009)
Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures
Dennis R. Sparta et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats
Nicholas W. Gilpin et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice
Emily G. Lowery et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Chronic Stress, Drug Use, and Vulnerability to Addiction
Rajita Sinha
ADDICTION REVIEWS 2008 (2008)
Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
Dorothea Blomeyer et al.
BIOLOGICAL PSYCHIATRY (2008)
Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala Crhr1 expression following a history of dependence
Wolfgang H. Sommer et al.
BIOLOGICAL PSYCHIATRY (2008)
Synaptic physiology of central CRH system
Joel P. Gallagher et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
Yu Fu et al.
JOURNAL OF NEUROSCIENCE (2008)
Disruption of the CRF2 receptor pathway decreases the somatic expression of opiate withdrawal
Francesco Papaleo et al.
NEUROPSYCHOPHARMACOLOGY (2008)
Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP
Mary-Anne Enoch et al.
PLOS ONE (2008)
MPZP:: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
Heather N. Richardson et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)
Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol:: A urocortin1-independent mechanism
Raul Pastor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats
Sheila E. Specio et al.
PSYCHOPHARMACOLOGY (2008)
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
Peter W. Marinelli et al.
PSYCHOPHARMACOLOGY (2007)
Corticotropin releasing factor-1 receptor antagonist, CP-154,526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice
J. R. Fee et al.
NEUROSCIENCE (2007)
Synaptic plasticity and addiction
Julie A. Kauer et al.
NATURE REVIEWS NEUROSCIENCE (2007)
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Olivier George et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
Kelly H. Skelton et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
Yu Zhao et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2007)
Stress-induced relapse to cocaine seeking:: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat
Bin Wang et al.
PSYCHOPHARMACOLOGY (2007)
Stress, dysregulation of drug reward pathways, and the transition to drug dependence
George Koob et al.
AMERICAN JOURNAL OF PSYCHIATRY (2007)
Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder
Vincenzo De Luca et al.
EUROPEAN PSYCHIATRY (2007)
A CRF2 agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats
Cindy K. Funk et al.
BRAIN RESEARCH (2007)
Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)
Deborah A. Finn et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2007)
Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity
Anja Schierloh et al.
NEUROSCIENCE LETTERS (2007)
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF, receptor antagonist antalarmin and by CRF, receptor knockout
Kathleen Chu et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2007)
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine:: A novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
Donald R. Gehlert et al.
JOURNAL OF NEUROSCIENCE (2007)
The neuropeptide corticotropin-releasing factor regulates excitatory transmission and plasticity at the climbing fibre-Purkinje cell synapse
M. T. Schmolesky et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal
Francesco Papaleo et al.
NEURON (2007)
CP-154,526, a CRF type-1 receptor antagonist, attenuates the cue-and methamphetamine-induced reinstatement of extinguished methamphetamine-seeking behavior in rats
M. C. Moffett et al.
PSYCHOPHARMACOLOGY (2007)
Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the alpha 2-adrenergic recpetor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats
George Zislis et al.
NEUROPHARMACOLOGY (2007)
Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats
Adrie W. Bruijnzeel et al.
NEUROPSYCHOPHARMACOLOGY (2007)
Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors
Yu Fu et al.
JOURNAL OF NEUROPHYSIOLOGY (2007)
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
Cindy K. Funk et al.
BIOLOGICAL PSYCHIATRY (2007)
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
Valentina Sabino et al.
PSYCHOPHARMACOLOGY (2006)
Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
Nancy K. Mello et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)
Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats
Cindy K. Funk et al.
JOURNAL OF NEUROSCIENCE (2006)
Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress
A. C. Hansson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis
Thomas L. Kash et al.
NEUROPHARMACOLOGY (2006)
A role for corticotropin-releasing factor, but not corticosterone, in acute food-deprivation-induced reinstatement of heroin seeking in rats
Uri Shalev et al.
PSYCHOPHARMACOLOGY (2006)
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
J. Treutlein et al.
MOLECULAR PSYCHIATRY (2006)
Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats
JS Wang et al.
PSYCHOPHARMACOLOGY (2006)
Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress
SC Coste et al.
GENES BRAIN AND BEHAVIOR (2006)
Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF1, NMDA receptors and PKA
Sebastian Pollandt et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal
A Contarino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications
JM Bossert et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence
AW Bruijnzeel et al.
BRAIN RESEARCH REVIEWS (2005)
Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats
E Przegalinski et al.
NEUROPEPTIDES (2005)
Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior:: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
GR Breese et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: A role in stress-induced relapse to drug seeking
B Wang et al.
JOURNAL OF NEUROSCIENCE (2005)
Inhibition of the central extended amygdala by loud noise and restraint stress
HEW Day et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
L Stinus et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders
DG Rainnie et al.
JOURNAL OF NEUROSCIENCE (2004)
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress
SE Hammack et al.
BEHAVIORAL NEUROSCIENCE (2004)
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors
ZG Nie et al.
SCIENCE (2004)
Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
DH Overstreet et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2004)
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
DJ Knapp et al.
ALCOHOL (2004)
Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure-activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists
C Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
The therapeutic potential of CRF1 antagonists for anxiety
EP Zorrilla et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2004)
Increased anxiety-like behavior and ethanol self-administration in dependent rats: Reversal via corticotropin-releasing factor-2 receptor activation
GR Valdez et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2004)
Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: Evidence for an allostatic shift?
L Caberlotto et al.
NEUROPSYCHOPHARMACOLOGY (2004)
The impact of stress on addiction
NE Goeders
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2003)
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
MB Müller et al.
NATURE NEUROSCIENCE (2003)
Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand:: Synthesis of [76Br]MJL-1-109-2
E Jagoda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellum
JD Swinny et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats
S Okada et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors
CL Rivier et al.
ENDOCRINOLOGY (2003)
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine
Y Zhou et al.
MOLECULAR BRAIN RESEARCH (2003)
Corticotropin releasing factor antagonist, α-helical CRF9-41, reverses nicotine-induced conditioned, but not unconditioned, anxiety
S Tucci et al.
PSYCHOPHARMACOLOGY (2003)
Morphine and cocaine influence on CRF biosynthesis in the rat central nucleus of amygdala
M Maj et al.
NEUROPEPTIDES (2003)
Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
GR Valdez et al.
ALCOHOL (2003)
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
HE Kunzel et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2003)
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
EP Zorrilla et al.
BRAIN RESEARCH (2002)
Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist
SC Heinrichs et al.
NEUROPSYCHOPHARMACOLOGY (2002)
Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake
MF Olive et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2002)
Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats
NE Goeders et al.
PSYCHOPHARMACOLOGY (2002)
Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist
C Keller et al.
DRUG METABOLISM AND DISPOSITION (2002)
Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
EP Zorrilla et al.
PSYCHOPHARMACOLOGY (2001)
Corticotropin-releasing factor receptor type 1 mediates stress-induced relapse to cocaine-conditioned place preference in rats
L Lu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
The anxiolytic effect of the CRH1 receptor antagonist R121919 depends on innate emotionality in rats
ME Keck et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
Compulsive drug-seeking behavior and relapse - Neuroadaptation, stress, and conditioning factors
F Weiss et al.
BIOLOGICAL BASIS OF COCAINE ADDICTION (2001)
Rat cerebral cortex corticotropin-releasing hormone receptors: evidence for receptor coupling to multiple G-proteins
DK Grammatopoulos et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats
NE Goeders et al.
NEUROPSYCHOPHARMACOLOGY (2000)
Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats
L Lu et al.
NEUROREPORT (2000)
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats
AD Lê et al.
PSYCHOPHARMACOLOGY (2000)
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression:: the first 20 patients treated
AW Zobel et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2000)
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
TL Bale et al.
NATURE GENETICS (2000)
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
T Kishimoto et al.
NATURE GENETICS (2000)
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
SC Coste et al.
NATURE GENETICS (2000)
Role of corticotropin-releasing factor receptor-1 in opiate withdrawal
PA Iredale et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Share Paper
