Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 13, Issue 5, Pages 755-764Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527312666131223113521
Keywords
Adenomatous polyposis coli; glycogen synthase kinase-3; schizophrenia; Wnt signaling pathway
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Funding
- National Natural Science Foundation of China [306770755, 81171266, 81271481]
- Shanghai Pujiang Program [10PJ1408800]
- Shanghai Scientific and Technological Innovation Project [11140900400]
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The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better understanding of the Wnt pathway might contribute to developing new and more effective tools for diagnosis and treatment of schizophrenia.
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