Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 29, Issue 4, Pages 517-522Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2015.1011117
Keywords
Daytime deliveries; dinoprostone; induction of labour; misoprostol; retrievable prostaglandin vaginal delivery systems
Categories
Funding
- Ferring Pharmaceuticals
- Ferring Pharmaceuticals, Inc.
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Objective: To determine induction start time(s) that would maximise daytime deliveries when using prostaglandin vaginal inserts.Methods: Women enrolled into the Phase III trial, EXPEDITE (clinical trial registration: NCT01127581), had labour induced with either a misoprostol or dinoprostone vaginal insert (MVI or DVI). A secondary analysis was conducted to determine the optimal start times for induction by identifying the 12-h period with the highest proportion of deliveries by parity and treatment.Results: Optimal start times for achieving daytime deliveries when using MVI appear to be 19:00 in nulliparae and 23:00 in multiparae. Applying these start times, the median time of onset of active labour would be approximately 08:30 for both parities and the median time of delivery would be the following day at approximately 16:30 for nulliparae and 12:00 (midday) for multiparae. Optimal start times when using DVI appear to be 07:00 for nulliparae and 23:00 for multiparae. Using these start times, the median time of onset of active labour would be the following day at approximately 04:00 and 11:50, and the median time of delivery would be approximately 13:40 and 16:10, respectively.Conclusions: When optimising daytime deliveries, different times to initiate induction of labour may be appropriate depending on parity and the type of retrievable prostaglandin vaginal insert used.
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