Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 10, Issue 2, Pages 235-238Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/187152711794480456
Keywords
Angiogenesis; cell survival; cellular signal pathway; ginsenoside Rg1; hypoxia inducible factor-1 alpha; hypoxia/ischemia brain damage; neurogenesis
Categories
Funding
- National Natural Science Foundation of China [30825039, 30973236, 30770 748]
- Chengdu University of Traditional Chinese Medicine [ZRYB200939]
Ask authors/readers for more resources
Hypoxia/ischemia brain damage (HIBD) is one of the most common central nervous system insults in newborns. Brain repair following HIBD is closely associated with cellular processes such as cell survival, angiogenesis, and neurogenesis. In recent years, many studies have suggested that ginsenoside Rg1, one of the major active ingredients of ginseng, may increase neural viability, promote angiogenesis, and induce neurogenesis. However, there are few reports on roles of Rg1 in HIBD repair, and the mechanisms involved are unclear. Recently, a Chinese drug consisting of Rg1 has been shown to be a potential regulator of hypoxia-inducible factor-1 alpha expression in HIBD. Since it has been shown that HIF-1 alpha is a key transcription factor involved in the neuroprotective response to HIBD, it is possible that Rg1 could facilitate the process of brain repair, possibly modulating cell survival, angiogenesis, and neurogenesis after HIBD by targeting HIF-1 alpha.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available