Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 8, Issue 4, Pages 281-295Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/187152709788921663
Keywords
Orexin; orphan GPCR; hypothalamus; narcolepsy-cataplexy; sleep/wake; energy homeostasis; reward; emotion
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- Japan Science and Technology Corporation
- Japanese Ministry of Health, Labor and Welfare
- Human Frontier Science Program
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Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy. Furthermore, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that regulate emotion, reward, and energy homeostasis. This review presents and discusses the current understanding of the integrative physiology of the orexin system.
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