Journal
CLINICS IN PERINATOLOGY
Volume 41, Issue 1, Pages 47-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2013.09.007
Keywords
Germinal matrix hemorrhage; Intraventricular hemorrhage; Astrocytes; Pericytes; Angiogenesis; Glucocorticoids; Premature infants; Indomethacin
Categories
Funding
- NINDS NIH HHS [R01 NS071263] Funding Source: Medline
Ask authors/readers for more resources
Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available