Journal
CLINICS IN PERINATOLOGY
Volume 41, Issue 2, Pages 423-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2014.02.011
Keywords
Mucosal innate immune system; Human breast milk; Bioactive factors; Lactoferrin; Antimicrobial peptides; Commensal bacteria; Intestinal microbiome
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Funding
- NICHD NIH HHS [R01 HD059122] Funding Source: Medline
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The gastrointestinal (GI) tract is a large potential portal for multiple infectious agents to enter the human body. The GI system performs multiple functions as part of the neonate's innate immune system, providing critical defense during a vulnerable period. Multiple mechanisms and actions are enhanced by the presence of human breast milk. Bioactive factors found in human milk work together to create and maintain an optimal and healthy environment, allowing the intestines to deliver ideal nutrition to the host and afford protection by a variety of mechanisms.
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