Journal
CLINICS IN PERINATOLOGY
Volume 38, Issue 2, Pages 321-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2011.03.008
Keywords
Microbiota; Mode of delivery; Hygiene hypothesis
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Funding
- NICHD NIH HHS [R01 HD059143, R01 HD059143-03] Funding Source: Medline
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Concurrent with the trend of increasing cesarean delivery numbers, there has been an epidemic of both autoimmune diseases and allergic diseases. Several theories have emerged suggesting that environmental influences are contributing to this phenomenon, most notably, the hygiene hypothesis. This article provides background about the human microbiota and its relationship to the developing immune system as well as the relationship of mode of delivery on the colonization of the infant intestine, development of the immune system, and subsequent childhood allergies, asthma, and autoimmune diseases.
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