Journal
CLINICS IN PERINATOLOGY
Volume 36, Issue 3, Pages 579-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2009.06.007
Keywords
Perinatal asphyxia; Hypoxic-ischemic encephalopathy; Fetal sheep; Premature delivery; Neuronal loss; Repeated hypoxia
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Funding
- Health Research Council of New Zealand
- Lottery Health Board of New Zealand
- Auckland Medical Research Foundation
- March of Dimes Birth Defects Trust
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The outcome of perinatal hypoxiaischemia is highly variable, with only a very broad relationship to the 'severity' of oxygen debt as shown by peripheral base deficit and the risk of damage. The present article examines the pathophysiology of asphyxial injury. We dissect the multiple factors that modify the risk of injury, including the depth ('severity'), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation.
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