Journal
CLINICS IN PERINATOLOGY
Volume 36, Issue 4, Pages 791-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2009.07.010
Keywords
Prematurity; Autism spectrum disorders; Brain; MRI; Outcome
Categories
Funding
- Canada Research Chairs Program, Canada Research Chair in Brain and Development
- LifeBridge Fund
- Trust Family Foundation
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Recent studies in survivors of extreme prematurity point to an increased prevalence of a previously underrecognized atypical social-behavioral profile strongly suggestive of an autism spectrum disorder. Prospective studies that incorporate early autism screening and autism diagnostic testing are needed to better delineate the sensitivity and specificity of early signs of autism in ex-premature children. Advances in neonatal MRI techniques capable of quantitative structural and functional measurements will also provide important insights into the effects of prematurity itself, and prematurity-related brain injury on the genesis of autism spectrum disorders in this population. Available evidence linking prematurity and autism spectrum disorders is reviewed in this article.
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