Journal
CLINICS IN PERINATOLOGY
Volume 36, Issue 4, Pages 859-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2009.07.013
Keywords
Neonatal stroke; Hypoxia; Ischemia; Neuroprotection; Neurogenesis
Categories
Funding
- NINDS NIH HHS [R01 NS033997, R01 NS033997-04, P50 NS035902-12, P50 NS035902] Funding Source: Medline
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Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.
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