Journal
CLINICS IN LIVER DISEASE
Volume 17, Issue 4, Pages 507-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2013.07.002
Keywords
Idiosyncratic drug-induced liver injury; Cell death; Reactive metabolites; Oxidative stress; Stress signaling; Mitochondria; Adaptive immunity; HLA associations
Categories
Funding
- NIDDK NIH HHS [R01 DK067215, P30 DK048522] Funding Source: Medline
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Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).
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