Journal
CLINICS IN LIVER DISEASE
Volume 17, Issue 4, Pages 643-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2013.07.009
Keywords
Nonsteroidal anti-inflammatory drugs; Drug-induced liver injury; Acute liver injury; Liver transplantation; Idiosyncratic hepatotoxicity; Hy's law; Drug safety; Drug surveillance
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Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.
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