Journal
CLINICS IN LIVER DISEASE
Volume 16, Issue 4, Pages 667-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2012.08.002
Keywords
Alcohol dehydrogenase; Cytochrome P4502E1; Acetaldehyde metabolism; Hepatic redox state; Alcohol absorption; Distribution and elimination; Isoforms of alcohol dehydrogenase; Metabolic adaptation to alcohol
Categories
Funding
- NIAAA NIH HHS [R01 AA018790, R01 AA017425, R21 AA021362] Funding Source: Medline
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This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabolism of alcohol are described. Most alcohol is oxidized in the liver, and general principles and overall mechanisms for alcohol oxidation are summarized. The kinetics of alcohol elimination in-vivo and the various genetic and environmental factors that can modify the rate of alcohol metabolism are discussed.
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